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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Propofol
Research Papers that Mention the Interaction
“ Propofol also inhibited the H2O2-induced reactive oxygen species (ROS) generation, lactic dehydrogenase (LDH) release and mitochondrial transmembrane potential (ΔΨm) depolarization, and restored the H2O2-induced reductions of glutathione (GSH) and superoxide dismutase (SOD).”
Propofol attenuates H2O2-induced oxidative stress and apoptosis via the mitochondria- and ER-medicated pathways in neonatal rat cardiomyocytes“ Propofol also increased the GSH levels and the mRNA and protein levels of Nrf2.”
“Moreover, propofol increased the antioxidant defense of glutathione.”
“ Propofol decreased thiobarbituric acid reactive substances production by 25.7% and increased total glutathione content by 24.6%.”
“The percentage of glutathione in oxidized form was 29.5% smaller in patients anesthetized with propofol.”
“Conclusion Treatment with isoflurane or propofol may enhance GSH production by facilitating translocation of Nrf2 into the nucleus and increasing EAAC1mRNA expression in the rat hippocampus.”
Effects of propofol and isoflurane on excitatory amino acid carrier 1 mRNA and glutathione protein levels in rat hippocampus“Introducing propofol (2 and 5 microM) restored the protective effect of GSH.”
“ Propofol significantly (P < 0.05) increased the levels of the hepatic reduced glutathione ( GSH ) and activities of GSH-dependent enzymes.”
Effects of Propofol, a Sedative-Hypnotic Drug, on the Lipid Profile, Antioxidant Indices, and Cardiovascular Marker Enzymes in Wistar Rats
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