Possible Interaction: Glutathione and Probenecid

“ GSH release in Jurkat cells undergoing apoptosis was inhibited by the organic anion transport inhibitors MK571, sulfinpyrazone, and probenecid , supporting a role for the MRP transporters in this process.”

“Two organic anion transporter inhibitors, probenecid and dibromosulfophthalein (DBSP), were effective in inhibiting Fas-stimulated GSH release.”

“However, probenecid caused a clear decrease in release of GSH from resistant cells into the medium.”

“At 24 h, both probenecid and NAC inhibited trauma-induced intracellular GSH depletion, lactate dehydrogenase (LDH) release, and propidium iodide (PI) uptake in both XY- and XX-neurons.”

“ Probenecid (1 mM) blocked resting or nifedipine-stimulated GSH secretion but only weakly inhibited BSP excretion.”

“However, S-alkyl glutathiones (hexyl and octyl), sulfobromophthalein-glutathione, glutathione monoethyl ester, probenecid (5 mM) and ophthalmic acid (10 mM) inhibited GSH uptake significantly.”

“ Probenecid prevented Cld accumulation, tubule injury, ATP depletion, and lipid peroxidation and markedly attenuated the GSH depletion.”

“Addition of inhibitors of this transport system, gamma-glutamyl-glutamate and probenecid , prevented the protection against injury afforded by GSH.”

“The rate of GSH uptake by the vesicles was enhanced by valinomycin-induced K+-diffusion potential (vesicle inside-positive) and was inhibited by probenecid , indicating that GSH transport across the canalicular membranes is electrogenic and involves the transfer of negative charge.”

“Abstract Cephalothin, penicillin G and probenecid inhibited GSH organic nitrate ester reductase (ONER) and several other enzymatic activities of GSH- S -transferases (EC 2.5.1.18) from rat and guinea pig liver.”