Possible Interaction: Glutathione and Polyphenols

“The results showed AP can decelerate the gastric lesion, significantly suppress lipid peroxidation, increase the level of glutathione and the activity of catalase, and regulate the MAPK signaling proteins.”

“Importantly, the polyphenol coating (EGCg) used in this study could be biodegraded by acidic pH and intracellular glutathione , resulting in the release of trapped anticancer drugs.”

“The order of catalytic effectiveness found for oxygen activation when polyphenolics were metabolized by peroxidase in the presence of GSH was phloretin>phloridzin>4,2'-dihydroxy chalcone>p-coumaric acid>naringenin>apigenin>curcumin>resveratrol>isoliquiritigenin>capsaicin>kaempferol.”

“More importantly, the high level of intracellular glutathione GSH ) could induce the biodegradation of the polyphenol coatings , resulting in a fast release of trapped anticancer drugs in the cells.”

“Further studies found that AP decreased the contents of NO and MDA and increased the levels of T-AOC and GSH in the hippocampus of rats.”

“Thus, ingestion of pomegranate polyphenols is associated with inhibition of x-ray–induced genomic instability and elevated GSH , which may reduce cancer risk.”

“ TPs administration could effectively reverse the alterations in the concentrations of 5-HT and NE, elevate the activities of SOD and CAT as well as the level of GSH , reduce the MDA level and inhibit lipid peroxidation.”

“In addition, tea polyphenols and diallyl trisulfide could increase glutathione S-transferase activity remarkably.”

“The recovery of the depleted GSH was significantly greater in the polyphenols (77.0 ± 12.0%) or VZS (67.0 ± 17.0%) treatment groups compared with the placebo group (36.0 ± 7.0%).”

“Changes in the GSH pathway induced by RWp were associated with a slight but significant increase in reactive oxygen species (ROS).”

“Hence, treatment of human erythrocytes with RWp (73 μg/mL Gallic Acid Equivalents) increased GSH intracellular concentration, which depends upon the activation of glutathione reductase (GR) and glucose-6-phosphate dehydrogenase (G6PD), whose enzymatic activities increase of about 30% and 47%, respectively.”