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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Glutathione and Piperonyl Butoxide

supplement:

Glutathione

drug:

Piperonyl Butoxide

Research Papers that Mention the Interaction

“this depletion of glutathione was prevented essentially by pretreatment with piperonyl butoxide.”
Mechanism for isaxonine hepatitis. II. Protective role of glutathione and toxicological studies in mice.
The Journal of pharmacology and experimental therapeutics  •  1984  |  View Paper
“Pretreatment of rats with either phenobarbital or piperonyl butoxide decreased the level of radiolabeled material bound in lung, GSH depletion, and the toxicity of OOS-TMP.”
Role of metabolic activation, covalent binding, and glutathione depletion in pulmonary toxicity produced by an impurity of malathion.
Toxicology and applied pharmacology  •  1984  |  View Paper
“Prior treatment with the drug metabolism inhibitor, piperonyl butoxide , markedly decreased the covalent binding, glutathione depletion , and the toxicity of 4-ipomeanol.”
In vivo studies on the target tissue metabolism, covalent binding, glutathione depletion, and toxicity of 4-ipomeanol in birds, species deficient in pulmonary enzymes for metabolic activation.
Toxicology and applied pharmacology  •  1982  |  View Paper
“Pretreatment of animals with piperonyl butoxide , an inhibitor of the metabolic activation of 4-ipomeanol, prevented both the depletion of lung glutathione and the pulmonary toxicity of 4-ipomeanol.”
Protective role of endogenous pulmonary glutathione and other sulfhydryl compounds against lung damage by alkylating agents. Investigations with 4-ipomeanol in the rat.
Biochemical pharmacology  •  1982  |  View Paper