Possible Interaction: Glutathione and Pimagedine

“This indicates that when CP was used as a cytostatic, GSH level rose after treatment with its combination with both AC and aminoguanidine.”

“ AG treatment significantly decreased MDA, TOS and OSI levels and increased SOD, CAT, GPX and GSH levels, when compared to the RT‐treated groups in both kidney and testis tissue.”

“On the other hand, AG , given together TCDD, reversed TCDD effects on TBARS SOD, GSH , GPx and CAT.”

“In the diabetic and nondiabetic groups, AG administration significantly reduced the MDA and NO levels and significantly increased GSH content and SOD enzyme activity.”

“Also, during the treatment with AG and NAC, GSH concentration was increased compared to the untreated animals (p<0.05).”

“Pretreatment with AG prevented CP-induced lipid peroxidation, protein oxidation, depletion of reduced GSH , and loss of activities of the antioxidant enzymes including GPx, catalase, and GSTase and also MPO activity.”

“Compared to …, AG at the dosage of 150mg/kg induced a reduction in the permeability of blood-spinal cord barrier (BSCB) after injury 48h (from …/g to 39.8+/-3.8microl/g), a 38% decrease of Malondialdehyde (MDA) values and a 1-fold increase of the Glutathione ( GSH ) levels ….”

“Free radical level was significantly lowered, whereas reduced glutathione level was significantly increased by aminoguanidine treatment in the aortic tissues from SHR.”

“The levels of GSH in aminoguanidine‐treated rats were significantly higher than those of the control group (p < 0.01).”

“In cortex AG decreases to a lower degree the concentration of Cys, CC, GSH but in this brain part significantly decreases ROS levels and increases SS.”