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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glutathione
drug:
Phenytoin
Research Papers that Mention the Interaction
“Liver slices (200 microm) were prepared from second trimester prenatal livers and cultured in the presence of 0, 250 microM, and 1000 microM phenytoin for 18 h. Exposure to 1000 microM phenytoin elicited 41% and 34% reductions in slice intracellular potassium and reduced glutathione ( GSH ) concentrations, respectively.”
“The reduction in slice GSH concentrations at 1000 microM phenytoin was accompanied by a 2.2-fold increase in the percentage of total slice glutathione consisting of GSSG, and a 3.9-fold increase in hGSTA1 steady-state mRNA expression.”
Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices.“ Glutathione , catalase, superoxide dismutase, azide, and indomethacin all diminished the metabolism of phenytoin and the covalent binding of its reactive intermediates.”
“ GSH and PON-1 activity increased after capsaicin, phenytoin or capsaicin/phenytoin.”
“ PHT treatment significantly (p < 0.05) increased superoxide dismutase (SOD) and catalase (CAT) activities, elevated lipid peroxidation (LPO) and hydrogen peroxide (H2O2) levels along with significant reduction in the hepatic and testicular levels of glutathione (GSH).”
Modulatory Role of Kolaviron in Phenytoin-Induced Hepatic and Testicular Dysfunctions in Wistar Rats“We recently demonstrated that DPH treatment decreased hepatic glutathione (GSH) contents, and GSH-depleted condition exacerbated DPH-induced liver injury in mice.”
“Chronic administration of phenytoin also produced significant elevations in brain MDA and reduction of brain GSH levels.”
“ PHT increased the activity of NAGA and decreased the level of GSH in foetal organs (liver, lungs, brain).”
“ PHT decreased the level of GSH and increased the activity of NAGA in foetal organs, the improvement occurred in the liver and lungs, but not in foetal brain.”
“ Phenytoin , a known inducer of oxidative stress, caused a decrease in glutathione content and an increase in susceptibility to lipid peroxidation in both liver and brain and increased oxidative DNA damage in brain.”
“ Phenytoin also enhanced the oxidation of embryonic glutathione ( GSH ) to its GSSG disulfide, as measured by HPLC (p < .05).”
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