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Last Updated: 2 years ago

Possible Interaction: Glutathione and Phenylephrine

supplement:

Glutathione

Research Papers that Mention the Interaction

In hepatocytes 10 μM adrenaline (Adr), but not isoproterenol (Iso) a β-AR agonist, or phenylephrine (Phe) an α1-AR agonist, (in a Krebs-Henseleit buffer (KHB) enriched with Ca2+ and some aminoacids) increased in 13% GT efflux.
Archives of biochemistry and biophysics  •  2018  |  View Paper
Phenylephrine produced a dose-dependent depression in hepatic glutathione levels when administered by the intraperitoneal (i.p.)
Toxicology  •  1991  |  View Paper
Phenylephrine , vasopressin, and phorbol ester also inhibited GSH synthesis in cultured cells by approximately 20%, and depleted cell GSH independent of the type of sulfur amino acid precursor.
The Journal of clinical investigation  •  1991  |  View Paper
Oral administration of phenylephrine with GSH caused a two‐ to fivefold transient increase in plasma GSH concentrations in rats.
Studies with isolated small intestinal epithelial cells showed that phenylephrine also stimulated the release of GSH from the cells.
The α‐adrenergic agonist, phenylephrine (1.6 μm), caused a threefold stimulation of glutathione (GSH) transport from the lumen into the vasculature in isolated, vascularly perfused rat small intestine.
Under physiological luminal GSH concentrations, phenylephrine stimulated GSH efflux from the lumen, accumulation in the intestinal mucosa, and transport into the mesenteric vasculature.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1991  |  View Paper