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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Phenylephrine
Research Papers that Mention the Interaction
“In hepatocytes 10 μM adrenaline (Adr), but not isoproterenol (Iso) a β-AR agonist, or phenylephrine (Phe) an α1-AR agonist, (in a Krebs-Henseleit buffer (KHB) enriched with Ca2+ and some aminoacids) increased in 13% GT efflux.”
β- Adrenoceptors activate hepatic glutathione efflux through an unreported pathway.“ Phenylephrine produced a dose-dependent depression in hepatic glutathione levels when administered by the intraperitoneal (i.p.)”
“ Phenylephrine , vasopressin, and phorbol ester also inhibited GSH synthesis in cultured cells by approximately 20%, and depleted cell GSH independent of the type of sulfur amino acid precursor.”
“Oral administration of phenylephrine with GSH caused a two‐ to fivefold transient increase in plasma GSH concentrations in rats.”
“Studies with isolated small intestinal epithelial cells showed that phenylephrine also stimulated the release of GSH from the cells.”
“The α‐adrenergic agonist, phenylephrine (1.6 μm), caused a threefold stimulation of glutathione (GSH) transport from the lumen into the vasculature in isolated, vascularly perfused rat small intestine.”
“Under physiological luminal GSH concentrations, phenylephrine stimulated GSH efflux from the lumen, accumulation in the intestinal mucosa, and transport into the mesenteric vasculature.”
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