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Last Updated: 2 years ago

Possible Interaction: Glutathione and Phenobarbital

supplement:

Glutathione

Research Papers that Mention the Interaction

However, 4 mM propylthiouracil did lead to a 50% increase in GSH reductase activity, and phenobarbital at 4 mM completely abolished GSH peroxidase and GSH reductase activity and led to a significant loss of viability.
Skin pharmacology : the official journal of the Skin Pharmacology Society  •  1993  |  View Paper
RESULTS Chronic feeding of p-dimethyl … benzene (p-DAB) and phenobarbital (PB e levated the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT), … (LDH), triglyceride, cholesterol, creatinine and bilirubin and lowered the levels of glutathione (GSH ), glucose-6-phosphate dehydrogenase (G-6-…), catalase and HDL-cholesterol.
Homeopathy : the journal of the Faculty of Homeopathy  •  2010  |  View Paper
Only phenobarbital pretreatment also significantly reduced GSH and ATP depletion.
Archives of Toxicology  •  2009  |  View Paper
Inducers of microsomal enzymes aroclor 1254 and phenobarbital notably inhibited glutathione S-transferase activity in animals with experimental pancreatitis on days 2–4 of the disease (3.1–2.5 times in comparison with sham-operated induced animals).
Bulletin of Experimental Biology and Medicine  •  2006  |  View Paper
Furthermore, we observe that the induction of chloramphenicol acetyltransferase (CAT) activity from an EpRE Ya-cat gene construct and of AP-1 binding activity by phenobarbital is inhibited by the thiol compounds N-acetyl-L-cysteine and glutathione.
The Biochemical journal  •  1993  |  View Paper
phenobarbital (80 mg/kg body weight, 4 days), ethanol (0.9 gm/kg body …), or diethylmaleate (3.9 mmol/kg body weight) resulted in changes in biliary glutathione secretion of +114%, -56%, and -95%, respectively, and in hepatic glutathione … -0%, +25%, and -86%, respectively, when compared with control values.
The Journal of laboratory and clinical medicine  •  1993  |  View Paper
Pretreatment of rats with phenobarbital or beta-naphthoflavone induced GSH S-transferases but did not increase the in vivo formation of DNA adducts, suggesting that concomitant induction of cytochrome P450 might abolish the effect of induction of GSH S-transferase by increasing the oxidation of ethylene dibromide.
Carcinogenesis  •  1990  |  View Paper
Our results clearly demonstrate that GSH S-transferase expression in seminal vesicles and pituitary glands can be suppressed by phenobarbital and diethylstilbestrol, respectively.
Biochemical and biophysical research communications  •  1986  |  View Paper
It is assumed that phenobarbital and PCN enhance the biliary excretion of these metals by increasing the transport of GSH , the carrier molecule, from liver to bile.
Acta pharmacologica et toxicologica  •  1985  |  View Paper
N-Benzylimidazole, an inhibitor of cytochrome P-450, completely blocked the response while phenobarbital pretreatment of the rats doubled the rate of GSH efflux.
Biochemical pharmacology  •  1985  |  View Paper
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