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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Penicillins
Research Papers that Mention the Interaction
“We observed that the presence of 10 mM GSH made MG1655 cells more susceptible to these b-lactams, because addition of GSH resulted in reduced MICs of ampicillin and penicillin from 8 and 64 mg/L to 4 and 48 mg/L, respectively.”
Temocillin susceptibility by BSAC methodology.“Here we present a detailed map of the GSH metabolic network of P. chrysogenum and show a promising way to keep the GSH pool selectively down under penicillin producing conditions.”
The glutathione metabolism of the beta-lactam producer filamentous fungus Penicillium chrysogenum.“The apparent Km of isopenicillin N synthetase for delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine was 0.13 mM. The enzyme activity was strongly inhibited by glutathione , which acts as a competitive inhibitor.”
“In the presence of penicillin , organisms respond quite differently to GSH and to an equivalent (concentrationwise) mixture of the component moieties of GSH.”
“ Glutathione , in appropriate concentrations, nullifies the slight depressing effect of low concentrations of penicillin (of the order of 4–5 micrograms/ml.)”
“addition of glutathione in concentrations from 0.1 to 100 times the molar concentration of the antibiotic seemed to increase the sensitivity of the organism to penicillin.”
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