Possible Interaction: Glutathione and Penicillamine

“An increase in intracellular glutathione levels in response to treatment with sodium aurothiomalate and penicillamine was demonstrated and considered to be related to these drugs' properties as thiols.”

“Moreover, penicillamine induces an increase of the reduced glutathion level which appears to be highly effective by interfering with oxidative cytotoxity of excess copper.”

“The ability of 'gold' treatment to normalise serum SH levels is of especial interest … portion of the drug molecule.8 In addition to serum SH changes, penicillamine … free glutathione in erythrocytes.9 The important role of SH/SS redox … ubiquitous function that the SH group displays in cellular physiology.”

“When glutathione is incubated with rat liver soluble proteins in the presence of penicillamine hydantoin, formation of oxidized glutathione is inhibited.”

“This suggests that, although both CP and PA may act as alternative sulphydryl nucleophiles to GSH to prevent arylation of essential cellular macromolecules by the reactive metabolite of paracetamol, the underlying mechanisms of these drug interactions may be distinctly different.”

“Kinetic analysis showed that the initial rate of reduction and equilibrium constant for the reduction of penicillamine disulfides by glutathione were 267- and 875-fold less than for captopril disulfide at pH 7.4.”