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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Glutathione and Parthenolide

supplement:

Glutathione

Research Papers that Mention the Interaction

We further determined that PTL perturbs glutathione homeostasis by a multifactorial mechanism, which includes inhibiting key glutathione metabolic enzymes (GCLC and GPX1), as well as direct depletion of glutathione.
The Journal of Biological Chemistry  •  2013  |  View Paper
Over 6 h, parthenolide at concentrations >5 microM markedly depleted intracellular glutathione and led to collapse of the mitochondrial membrane potential.
Free radical biology & medicine  •  2007  |  View Paper