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Last Updated: 2 years ago

Possible Interaction: Glutathione and Paclitaxel

supplement:

Glutathione

Research Papers that Mention the Interaction

In vitro, the formulation comprising 0.5% (m/… (100 kDa)/0.5% (m/v) GSH improved … of paclitaxel 6.7-fold (P(app) = 8.7 ± 1.3 × 10(-6) cm/s) in comparison to … serving as buffer only control (P(app) = 1.3 ± 0.4 × 10(-6) cm/s).
Biomaterials  •  2011  |  View Paper
Paclitaxel release from the nanoparticles in PBS buffer was accelerated in the presence of glutathione at both pH 5.5 and pH 7.4, reaching ca.
Molecular pharmaceutics  •  2013  |  View Paper
The HPLC results revealed that the NPs released almost 90% PTX within 96 h when GSH presented at intracellular concentrations, whereas only a very small PTX amount was released at plasma GSH levels.
Colloids and surfaces. B, Biointerfaces  •  2011  |  View Paper
Addition of N‐acetylcysteine (NAC) or glutathione , two H2O2 scavenger, induced a 4‐fold increase in paclitaxel IC50.
International journal of cancer  •  2006  |  View Paper
It is believed that GSH plays a role in the aquisition of resistance to anti-cancer drugs, such as a cisplatin, adriamycin, melphalan, or taxol.
Gan to kagaku ryoho. Cancer & chemotherapy  •  1997  |  View Paper
Taxol , VP-16, vincristine, and vinblastine were also poor inhibitors of LTC4 transport but inhibition by these compounds was enhanced by GSH.
The Journal of biological chemistry  •  1996  |  View Paper
Since cisplatin treatment led to a reduction in cellular glutathione content in these cells and reduced levels of glutathione have been associated with protection against cytotoxicity of paclitaxel , cells were pretreated with L-buthionine sulfoximine (L-BSO).
European journal of cancer  •  1995  |  View Paper
The NPs release PTX significantly faster at mildly acidic pH and high concentrations of GSH , exhibiting almost no burst release under the physiological conditions of plasma.
Biomaterials science  •  2019  |  View Paper
We hypothesized that the fluorescence intensity of paclitaxel (PTX)-MnO2/FCN would suddenly increase (fluorescence "on") in the presence of a high level of glutathione (GSH) in cancer cells, owing to the reduction of MnO2 to Mn2+ and cleavage of the disulfide bond.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences  •  2019  |  View Paper
Maximal apoptosis was detected with a paclitaxel pretreatment time of 20 h. Intracellular GSH levels were reduced by nearly 50% with paclitaxel pretreatment.
International journal of radiation oncology, biology, physics  •  2001  |  View Paper
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