Possible Interaction: Glutathione and Paclitaxel

“In vitro, the formulation comprising 0.5% (m/… (100 kDa)/0.5% (m/v) GSH improved … of paclitaxel 6.7-fold (P(app) = 8.7 ± 1.3 × 10(-6) cm/s) in comparison to … serving as buffer only control (P(app) = 1.3 ± 0.4 × 10(-6) cm/s).”

“ Paclitaxel release from the nanoparticles in PBS buffer was accelerated in the presence of glutathione at both pH 5.5 and pH 7.4, reaching ca.”

“The HPLC results revealed that the NPs released almost 90% PTX within 96 h when GSH presented at intracellular concentrations, whereas only a very small PTX amount was released at plasma GSH levels.”

“Addition of N‐acetylcysteine (NAC) or glutathione , two H2O2 scavenger, induced a 4‐fold increase in paclitaxel IC50.”

“It is believed that GSH plays a role in the aquisition of resistance to anti-cancer drugs, such as a cisplatin, adriamycin, melphalan, or taxol.”

“ Taxol , VP-16, vincristine, and vinblastine were also poor inhibitors of LTC4 transport but inhibition by these compounds was enhanced by GSH.”

“Since cisplatin treatment led to a reduction in cellular glutathione content in these cells and reduced levels of glutathione have been associated with protection against cytotoxicity of paclitaxel , cells were pretreated with L-buthionine sulfoximine (L-BSO).”

“The NPs release PTX significantly faster at mildly acidic pH and high concentrations of GSH , exhibiting almost no burst release under the physiological conditions of plasma.”

“We hypothesized that the fluorescence intensity of paclitaxel (PTX)-MnO2/FCN would suddenly increase (fluorescence "on") in the presence of a high level of glutathione (GSH) in cancer cells, owing to the reduction of MnO2 to Mn2+ and cleavage of the disulfide bond.”

“Maximal apoptosis was detected with a paclitaxel pretreatment time of 20 h. Intracellular GSH levels were reduced by nearly 50% with paclitaxel pretreatment.”