supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Glutathione
drug:
Omeprazole
Research Papers that Mention the Interaction
“Experiments in vitro and in vivo have shown that the reducing agent glutathione reverses the acid-inhibitory activity of omeprazole to a much greater degree than the activity of pantoprazole, most likely because glutathione cannot access cysteine 822.”
The basis of differentiation of PPIs.“In contrast, that of omeprazole was not influenced by dilution, but was suppressed by glutathione pretreatment.”
Studies on the mechanism of action of the gastric H+,K(+)-ATPase inhibitor SPI-447.“Hence, omeprazole was found to be a specific inhibitor of the H+,K(+)-ATPase under physiological conditions, i.e. in the presence of glutathione , while bafilomycin was found to be selective towards vacuolar H(+)-ATPases.”
“ Omeprazole was found to inhibit acid secretion, and the inhibition could be reversed with glutathione or 2-mercaptoethanol.”
“Biological reducing agents like cysteine or glutathione , however, were unable to reverse the inhibitory effect of omeprazole.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback