Possible Interaction: Glutathione and Oltipraz

“… GSH ) levels (total and mitochondrial) and glutathione S-transferase (…) activity were significantly increased after pretreatment with oltipraz in both parental (rho+) and rho0 cells, and both cell lines were resistant to mitochondrial oxidation, loss of mitochondrial membrane potential, and cell death in response to the GSH depleting agent diethylmaleate.”

“In this cell line, oltipraz resulted in increased activity of both GSH transferase and DT-diaphorase.”

“Induction was observed in both dose groups with a time lag between the maximum concentrations of oltipraz and that of GSH or GST.”

“These preliminary results indicate that oltipraz may be effective in inducing GSH and GST, an enzyme capable of carcinogen elimination.”

“Higher bile flow and glutathione secretion rates were observed in unoperated mice treated with oltipraz than in control mice, suggesting that liver necrosis in oltipraz-treated BDL mice may be related partially to increased bile-acid independent flow and biliary pressure.”

“In incubation with S. mansoni, addition of OPZ resulted in significantly increased production of MDA, together with depletion of GSH , both of which were time- and OPZ concentration-dependent.”