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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Norethindrone
Research Papers that Mention the Interaction
“Metabolomic analysis showed that the metabolic … antioxidant defence were disrupted by NET (e.g. upregulation of nervonyl carnitine and chenodeoxycholic acid 3-sulfate; downregulation of homolanthionine and acevaltrate) and these … antioxidant defence by suppressing Nrf2-ARE and NF-κB pathways that contribute to the synthesis of SOD and GSH.”
“While acute mortality was not triggered, … antioxidant defence was substantially weakened by NET at 500 ng/L (…. reduced SOD and GSH levels) and hence liver injury was inflicted (i.e. elevated ALT and MDA levels), … by vacuolization of liver tissues and reduced number of normal cells in the liver.”
Norethindrone causes cellular and hepatic injury in zebrafish by compromising the metabolic processes associated with antioxidant defence: Insights from metabolomics.
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