Possible Interaction: Glutathione and Nitroglycerin

“Furthermore, GSH potentiated the coronary dilator effect of nitroglycerin.”

“Because glutathione , which does not enter cells readily, also potentiated the effects of NTG , the possibility of an extracellular pathway for the thiol-organic nitrate interaction was examined.”

“In vitro degradation of NTG in plasma and blood was accelerated in the presence of NAC (or glutathione).”

“The hypotensive effect of NTG was enhanced significantly by NAC and glutathione , but not by N-acetylserine, showing clearly that the potentiating effect of NAC was due specifically to its thiol functional group.”

“ Glutathione infusion (600 mg as an intravenous bolus followed by 600 mg/h) was started 30 minutes before and was continued for 60 minutes after administration of glyceryl trinitrate.”

“In addition, treatment of rabbits with NTG induced a significant decrease in total GSH level and SOD activity by 46 and 53%, respectively, as compared with the control values.”

“Coadministration of GSH may reverse the advert action of high-dose NTG.”

“ Chronic nitroglycerin administration significantly increased NO levels (p < 0.05), GSH levels (p < 0.001), superoxide dismutase (SOD) activity (p < 0.05), GST activity (p < 0.05), and decreased MDA levels (p < 0.05).”

“The combination of exercise and nitroglycerin significantly enhanced GSH levels (p < 0.05), and the up-regulation of SOD (p < 0.001), GSH-Px (p < 0.05), GR (p < 0.05) and GST (p < 0.001) activities.”

“Subsequent exogenous administration of GTN at doses of 3 and 6mg/kg body weight resulted in significant (P<0.001) recovery of GSH metabolizing enzymes and amelioration of tissue GSH content, in a dose-dependent manner.”

“for 2 hours) significantly (p<0.05) increased extracellular cysteine and GSH levels and potentiated the hypotensive effect of NTG (from 26±3 to 31±4 mm Hg [mean+SEM], p<0.05).”

“three times within 24 hours) significantly decreased intracellular GSH levels (p<0.05) and attenuated the effect of NTG (from 28±3 to 16±2 mm Hg).”

“Infusion of N-acetylcysteine (0.245, 1.225 and 6.125 mmol/kg/h for 4 h) and, to a lesser extent, equimolar doses of reduced glutathione , but not N-acetylserine, significantly potentiated the hypotensive effect of NTG , in a dose-dependent manner (P less than .05).”

“We showed that a cellular-impermeant thiol, viz: glutathione , can also potentiate the hemodynamic effect of nitroglycerin in rats.”