Possible Interaction: Glutathione and Nitric Oxide

“IPH-NO can slowly release NO in the presence of glutathione to boost tumor vascular permeability and improve drug accumulation.”

“Additionally, NO led to an increase in TCA cycle flux and glutaminolysis, suggesting that NO decreases ROS levels by increasing NADPH and glutathione levels.”

“At the same time, NO induced elevation of reduced glutathione ( GSH ) and a mild activation of the antioxidant transcription factors Hypoxia-inducible factor 1α (HIF1α) and NF-E2 related factor 2 (Nrf-2).”

“Moreover, GSH depletion in macrophages leads to increased nitric oxide ( NO ) production, which has leishmanicidal action.”

“Collectively, NO stimulates Fe and GSH efflux from cells via MRP1.”

“Reversability of the impairment of lipogenesis by NO can be achieved by the addition of glutathione [1] which has a key funcLETTER TO THE EDITORS”

“In astrocytes in culture, highly selective depletion of this glutathione pool does not affect cell viability, at least in the first 24 h, but does greatly increase susceptibility to exposure to nitric oxide or peroxynitrite.”

“Some of the ways in which NO may affect mitochondria are by reacting with low-molecular-weight thiols such as glutathione and with protein thiols.”

“Co‐incubation with redox compounds, N‐acetyl‐L‐cysteine, glutathione and L‐ascorbic acid prevented NO inhibition of DNA synthesis.”

“Because nitric oxide NO ) reacts with various molecules, such as hemeproteins, superoxide and thiols including glutathione ( GSH ) and cysteine residues in proteins, biological effects and metabolic fate of this gaseous radical are affected by these reactants.”