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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Nifurtimox
Research Papers that Mention the Interaction
“We have previously shown that glutathione synthesis inhibition increases nifurtimox and benznidazole activity.”
Chagas disease: Present status of pathogenic mechanisms and chemotherapy.“Addition of GSH or free-radical scavengers (catalase, superoxide dismutase, mannitol, sodium benzoate or L-histidine) prevented the effect of nifurtimox on lipid peroxidation reactions.”
“Treatment of rats with nifurtimox , a nitrofuran derivative widely used for the treatment of Chagas' disease, induced a time- and dose-dependent depletion of liver glutathione , maximal effects being obtained with 200 mg nifurtimox/kg body weight.”
Increased biliary secretion and loss of hepatic glutathione in rat liver after nifurtimox treatment.
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