Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Glutathione and Nifurtimox



Research Papers that Mention the Interaction

We have previously shown that glutathione synthesis inhibition increases nifurtimox and benznidazole activity.
Biological research  •  2010  |  View Paper
Addition of GSH or free-radical scavengers (catalase, superoxide dismutase, mannitol, sodium benzoate or L-histidine) prevented the effect of nifurtimox on lipid peroxidation reactions.
Biochemical pharmacology  •  1984  |  View Paper
Treatment of rats with nifurtimox , a nitrofuran derivative widely used for the treatment of Chagas' disease, induced a time- and dose-dependent depletion of liver glutathione , maximal effects being obtained with 200 mg nifurtimox/kg body weight.
Biochemical pharmacology  •  1983  |  View Paper