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Last Updated: 3 years ago

Possible Interaction: Glutathione and Niacin





Research Papers that Mention the Interaction

Key findings: Nicotinamide restrained the HeLa cell proliferation and significantly increased the accumulation of ROS and depletion of GSH at relatively high concentrations.
Life sciences  •  2017  |  View Paper
Concentration of MDA and conjugated dienes was lower and the levels of reduced glutathione and vitamin E higher in the presence of nicotinic acid.
Vox Sanguinis  •  1999  |  View Paper
Furthermore, NA significantly elevated the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) content, while reduced malondialdehyde (MDA) level.
Journal of nutritional science and vitaminology  •  2021  |  View Paper
Niacin treatments (300, 600, and 900 μM) during IVM significantly (p < 0.05) enhanced glutathione levels.
Theriogenology  •  2021  |  View Paper
Specifically, NAM diminished the activity and expression of G6PD and ME, and this effect was associated with a decrease in the NADPH/NADP + ratios, increased GSH levels and decreased lipoperoxidation and inflammation, ameliorating fibrosis and NASH development.
Molecular Biology Reports  •  2019  |  View Paper
A high dose of niacin increased lung NAD+, nicotinamide adenine dinucleotide phosphate levels, and glutathione –glutathione disulfide ratios; decreased lung malondialdehyde levels; down-regulated the NF-&kgr;B pathway; suppressed TNF-&agr;, IL-6, and IL-8 levels in the lung tissue and serum; and attenuated histologic lung damage.
The journal of trauma and acute care surgery  •  2015  |  View Paper
Furthermore, Niacin reduces peroxynitite formation and improves antioxidant GSH.
PloS one  •  2014  |  View Paper
Dose-dependent improvement in the antioxidant defence system, enhanced reduced glutathione levels, lowered lipid peroxidation and higher hepatic Zn levels were observed with NA supplementation.
British Journal of Nutrition  •  2011  |  View Paper
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition  •  2000  |  View Paper
Reduced glutathione , on the contrary, clearly potentiates the contractile effect of nicotinic acid in the tissue.
Archives internationales de pharmacodynamie et de therapie  •  1983  |  View Paper
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