Possible Interaction: Glutathione and Ng-Nitroarginine Methyl Ester

“Moreover, topical application of L-NAME significantly alleviated the lens nitrite, opacity, antioxidants ( GSH , CAT, SOD, and GPx), MDA, proteins, and ionic (Na+ and Ca2+) contents.”

“Administration of L-NAME significantly attenuated TBARS (p<0.001), H(2)O(2) (p<0.05), TNF-alpha (p<0.01) and increased GSH (p<0.05) levels vs. ET-1.”

“ L-NAME (NO synthase inhibitor) caused significant elevation in serum creatinine, BUN, liver enzymes, liver histopathological damage score (p ≤ 0.05) and MDA production (p ≤ 0.001); on the other hand significantly decreased NO and GSH levels (p ≤ 0.05).”

“ l-NAME prevented the effect of SIL on GSH content (p < 0.001).”

“ L-NAME treatment in non-ischemic animals increased blood pressure and lipid peroxidation, and decreased glutathione level in myocardial tissue significantly as compared with non-L-NAME-treated animals.”

“We observed that L-NAME significantly increased both tissue and perfusate GSH levels and pulmonary artery pressures, but it decreased both tissue and perfusate MDA levels.”

“ L-NAME caused GSH depletion in the heart and kidney tissues with a concomitant increase in MDA contents in both the tissues.”

“In rat glial cells, arginine analogs N(G)-nitroarginine methyl ester (both D- and L-stereoisomer) and L-canavanine lower the intracellular levels of reduced glutathione , stimulate the pentose phosphate pathway, increase the level of malonyldialdehyde, and increase the leakage of lactate dehydrogenase.”

“However, L-NAME did not retreat the favorable effects of GSH , although it reduced the NOS activity without eliminating NO content, suggesting that NR might be a prospective source of NO generated by GSH in Cd-stressed plants, which in turn accelerated the activities of antioxidant enzymes.”

“The vasorelaxant effect of GSH in endotheliumintact rings was inhibited by glibenclamide (3 μM), methylene blue (10 μM) and N-nitro-L-arginine methyl ester (10 μM), indicating the involvement of membrane K+ channels and NO-cGMP pathway.”