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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Nerve Growth Factor
Research Papers that Mention the Interaction
“We present evidence that this inhibition is mediated by the rapid activation of glutathione redox cycling by NGF.”
Rapid Activation of Antioxidant Defenses by Nerve Growth Factor Suppresses Reactive Oxygen Species during Neuronal Apoptosis: Evidence for a Role in Cytochrome c Redistribution“ NGF was also shown to upregulate glutathione in DRG neurons.”
“ NGF prevented both the loss of viability seen after 24 hours amyloid beta treatment and also protected glutathione levels.”
“The increased GSH and L-cysteine concentrations by NGF also served as intracellular antioxidants.”
“Treatment with NGF or forskolin for 24 h increased the level of cellular antioxidant glutathione ( GSH ) by 1.6-2.0-fold.”
“ NGF increased catalase and GSH Px mRNA levels in PC 12 cells in a time‐ and dose‐dependent manner.”
“ NGF stimulated GSH peroxidase by 30% after 3 days and glucose 6‐phosphate dehydroge‐nase by 50% after 2 days.”
“Specifically, NGF increased γ‐glutamylcysteine synthetase (GCS) activity, the rate‐limiting enzyme for GSH synthesis, by 50% after 9h and GSH levels by 100% after 24 h of treatment.”
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