Possible Interaction: Glutathione and Naringenin

“ Naringenin reduced 6-OHDA induced oxidative stress biomarker levels such as CAT, GSH , SOD, and ROS.”

“Several flavonoids, especially naringenin and apigenin, markedly stimulated GSH transport by MRP1, suggesting they may be cotransported with this tripeptide.”

“ Naringenin also inhibited inflammasome upregulation (reduced Nlrp3, ASC, caspase-1, and … stress (reduced gp91phox mRNA expression and superoxide anion production, increased GSH levels, induced Nrf2 protein in CD45+ hematopoietic recruited cells, and induced Nrf2 and HO-… anti-inflammatory effects in zymosan-induced arthritis by targeting its main physiopathological mechanisms.”

“Further, naringenin inhibited alkali-induced cytokine (IL-1β and IL-6) production, Vegf, Pdgf, and Mmp14 mRNA expression, and the reduction of ferric reducing antioxidant power and Azinobis-(3-Ethylbenzothiazoline 6-Sulfonic acid) radical scavenging capacity as well as increased the reduced glutathione and protein-bound sulfhydryl groups levels.”

“RESULTS NAR administration prevented increases in ALT, AP, γ-GTP, and GPx enzymatic activity; depletion of GSH and glycogen; and increases in LPO and collagen produced by chronic CCl4 intoxication (P < 0.05).”

“In addition, naringenin increased the liver content of reduced glutathione and the activity of anti‐oxidant enzymes in rats treated with CCl4.”

“ NGN pretreatment significantly reduced stress-mediated apoptotic cell death and lipid peroxidation and showed increased level of reduced glutathione in H2O2-treated cardiomyoblast.”

“ Naringenin inhibits leukocyte recruitment [2-5] and production of superoxide anion [3-5], whilst increases GSH [2-4], and antioxidant capacity [3-5].”