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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
N-Methylformamide
Research Papers that Mention the Interaction
“ Glutathione may also play a role in the toxicity or action of several cancer chemotherapeutic agents, including N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), N-methylformamide , cyclophosphamide, neocarzinostatin, and bleomycin.”
Glutathione-dependent bioactivation of xenobiotics: implications for mutagenicity and carcinogenicity.“In BALB/c mice, the most susceptible strain, a hepatotoxic dose of NMF (200 mg/kg) caused a depletion of hepatic glutathione to 21% of control levels 2 hr after drug administration.”
“ Liver glutathione levels were depressed following 2-MF administration.”
“Indeed NMF appears to decrease hepatic levels of glutathione in vivo [4] and also to induce lipid peroxidation in isolated hepatocytes (Lundberg et al., unpublished results).”
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