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Last Updated: 2 years ago

Possible Interaction: Glutathione and Morphine

supplement:

Glutathione

Research Papers that Mention the Interaction

Glutathione binds not only morphine but also naloxone, methadone, and methionine enkephalin.
Morphine binds to glutathione (l-γ-glutamyl-l-cysteinyl-glycine), an intracellular ascorbic acid recycling molecule with a wide range of additional activities.
International journal of molecular sciences  •  2020  |  View Paper
Depletion of intracellular glutathione had a greater effect on increasing cellular morphine accumulation than P-glycoprotein inhibitors, suggesting a role for glutathione in morphine transport.
European journal of pharmacology  •  2002  |  View Paper
In macrophage cultures, glutathione (GSH) was upregulated strongly after treatment with dopamine, morphine or selegiline, and this effect was enhanced when cells were pre-exposed to virus.
Journal of neurovirology  •  1997  |  View Paper
Morphine (1 and 5mg/kg) attenuated RS induced anxiogenesis, changes in MDA and GSH but further enhanced Hsp70 expression.
European journal of pharmacology  •  2014  |  View Paper
GSH increased significantly in cortex and cerebellum/medulla oblongata of animals treated with morphine and lacosamide alone or combined with insulin.
Pakistan journal of biological sciences : PJBS  •  2014  |  View Paper
The increase in NO levels by morphine (100 microg, 5 min) was completely inhibited in the presence of naloxone (100 microg), L-NAME (125 microg) or GSH (100 microg).
Experimental eye research  •  2007  |  View Paper
IOP-lowering effect of morphine (100 µg) and reduction in PD were both significantly inhibited by pretreatment with naloxone (100 µg), L-NAME (0.5%), or GSH (100 µg).
Pharmacology  •  2006  |  View Paper
In conclusion, unsaturated fatty acids contents in brain and spinal cord sections and GSH were reduced by administrating spinal morphine although oxidative stress as LP increased.
LP levels in the cortex brain were increased although GSH levels were decreased by the morphine administration.
Neurochemical Research  •  2006  |  View Paper
Morphine significantly prevents the depletion of GSH by glutamate and thereby inhibits the generation of H2O2 in a dose‐dependent manner.
Immunopharmacology and immunotoxicology  •  2004  |  View Paper
Morphine also reduced the intracellular level of glutathione , namely, the oxidative and most abundant cell thiol.
These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione.
International journal of immunopharmacology  •  1999  |  View Paper
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