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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Morphine
Research Papers that Mention the Interaction
“ Glutathione binds not only morphine but also naloxone, methadone, and methionine enkephalin.”
“ Morphine binds to glutathione (l-γ-glutamyl-l-cysteinyl-glycine), an intracellular ascorbic acid recycling molecule with a wide range of additional activities.”
Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse“Depletion of intracellular glutathione had a greater effect on increasing cellular morphine accumulation than P-glycoprotein inhibitors, suggesting a role for glutathione in morphine transport.”
“In macrophage cultures, glutathione (GSH) was upregulated strongly after treatment with dopamine, morphine or selegiline, and this effect was enhanced when cells were pre-exposed to virus.”
“ Morphine (1 and 5mg/kg) attenuated RS induced anxiogenesis, changes in MDA and GSH but further enhanced Hsp70 expression.”
Differential modulatory effects of morphine on acute and chronic stress induced neurobehavioral and cellular markers in rats.“ GSH increased significantly in cortex and cerebellum/medulla oblongata of animals treated with morphine and lacosamide alone or combined with insulin.”
“The increase in NO levels by morphine (100 microg, 5 min) was completely inhibited in the presence of naloxone (100 microg), L-NAME (125 microg) or GSH (100 microg).”
“IOP-lowering effect of morphine (100 µg) and reduction in PD were both significantly inhibited by pretreatment with naloxone (100 µg), L-NAME (0.5%), or GSH (100 µg).”
“In conclusion, unsaturated fatty acids contents in brain and spinal cord sections and GSH were reduced by administrating spinal morphine although oxidative stress as LP increased.”
“LP levels in the cortex brain were increased although GSH levels were decreased by the morphine administration.”
“ Morphine significantly prevents the depletion of GSH by glutamate and thereby inhibits the generation of H2O2 in a dose‐dependent manner.”
“ Morphine also reduced the intracellular level of glutathione , namely, the oxidative and most abundant cell thiol.”
“These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione.”
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