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Possible Interaction: Glutathione and Misonidazole

supplement:

Glutathione

Research Papers that Mention the Interaction

Some biochemical repair processes, in particular those concerned with the rejoining of breaks induced by radiation in the presence of oxygen or misonidazole , appear also to be critically dependent on glutathione.
International journal of radiation biology and related studies in physics, chemistry, and medicine  •  1985  |  View Paper
During the course of the reaction, misonidazole undergoes a DNA-dependent reduction and subsequent conjugation with glutathione used to activate NCS-Chrom.
Proceedings of the National Academy of Sciences of the United States of America  •  1987  |  View Paper
The hydroxylamine derivative of misonidazole reacts with glutathione under physiological conditions to form two isomeric conjugates.
Biochemical and biophysical research communications  •  1983  |  View Paper
Misonidazole also reacts rapidly with glutathione in the presence of ferrous ions and is subsequently reduced: metronidazole is reduced only slowly if at all.
The British journal of cancer. Supplement  •  1978  |  View Paper
The protective effects of glutathione and thiourea were diminished by the addition of misonidazole.
Journal of radiation research  •  1984  |  View Paper
Depletion of intracellular glutathione GSH ) can enhance misonidazole (MISO) radiosensitizing efficacy both in vivo and in vitro.
International journal of radiation oncology, biology, physics  •  1984  |  View Paper
When CHO cells were incubated with misonidazole in the presence of added GSH , a substantial increase in the amount of the conjugate was detected.
When extracts of CHO cells exposed to misonidazole under hypoxia were subsequently exposed to GSH , an increased formation of the conjugate was observed.
International journal of radiation oncology, biology, physics  •  1984  |  View Paper
However, glutathione depletion caused a profound change in the radiosensitizing efficiency of misonidazole , with a decrease in Km of about sevenfold from 0.6 to 0.09 mM. In contrast, only a 2.5-fold decrease was found in the Km for radiosensitization by oxygen with diethylmaleate pretreatment.
Radiation research  •  1984  |  View Paper
The possible involvement of glutathione depletion in chemosensitization by MISO was investigated by comparison with the effect of diethyl maleate (DEM), a known thiol-depleting reagent.
British Journal of Cancer  •  1983  |  View Paper
Although … glutathione (GSH) occurs during … pretreatments with MISO , simulating the same magnitude of GSH depletion with the GSH depleter, diethylmaleate, gave a dose reduction factor of only 1.4, … GSH depletion would not be expected to contribute to the sensitization which occurs when MISO is given after L-PAM.
Cancer research  •  1983  |  View Paper
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