Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 8 months ago

Possible Interaction: Glutathione and Misonidazole



Research Papers that Mention the Interaction

Some biochemical repair processes, in particular those concerned with the rejoining of breaks induced by radiation in the presence of oxygen or misonidazole , appear also to be critically dependent on glutathione.
International journal of radiation biology and related studies in physics, chemistry, and medicine  •  1985  |  View Paper
The protective effects of glutathione and thiourea were diminished by the addition of misonidazole.
Journal of radiation research  •  1984  |  View Paper
Depletion of intracellular glutathione GSH ) can enhance misonidazole (MISO) radiosensitizing efficacy both in vivo and in vitro.
International journal of radiation oncology, biology, physics  •  1984  |  View Paper
When CHO cells were incubated with misonidazole in the presence of added GSH , a substantial increase in the amount of the conjugate was detected.
When extracts of CHO cells exposed to misonidazole under hypoxia were subsequently exposed to GSH , an increased formation of the conjugate was observed.
International journal of radiation oncology, biology, physics  •  1984  |  View Paper
However, glutathione depletion caused a profound change in the radiosensitizing efficiency of misonidazole , with a decrease in Km of about sevenfold from 0.6 to 0.09 mM. In contrast, only a 2.5-fold decrease was found in the Km for radiosensitization by oxygen with diethylmaleate pretreatment.
Radiation research  •  1984  |  View Paper
The possible involvement of glutathione depletion in chemosensitization by MISO was investigated by comparison with the effect of diethyl maleate (DEM), a known thiol-depleting reagent.
British Journal of Cancer  •  1983  |  View Paper
Although … glutathione (GSH) occurs during … pretreatments with MISO , simulating the same magnitude of GSH depletion with the GSH depleter, diethylmaleate, gave a dose reduction factor of only 1.4, … GSH depletion would not be expected to contribute to the sensitization which occurs when MISO is given after L-PAM.
Cancer research  •  1983  |  View Paper
These results demonstrate that glutathione protects against the cytotoxic effect of MIS.
Cancer research  •  1983  |  View Paper
Glutathione reduced the binding of misonidazole to microsomal protein below the level observed for boiled microsomes while ascorbic acid had no effect.
Biochemical pharmacology  •  1982  |  View Paper
Misonidazole (MISO) depletes intracellular glutathione and is more toxic in glutathione depleted cells.
International journal of radiation oncology, biology, physics  •  1982  |  View Paper
Show More