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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Metronidazole
Research Papers that Mention the Interaction
“ MTZ increased liver ethoxyresorufin-O-deethylase, malondialdehyde, and glutathione levels, and elevated the activities of superoxide dismutase, catalase, aspartate aminotransferase, and alanine aminotransferase.”
Detrimental Effects of Metronidazole on the Liver of Freshwater Common Carp (Cyprinus carpio L.)“The bioactivation was dependent on N2-atmosphere, and presence of the P450-inhibitor metyrapone or GSH in the incubation media depressed the protein-binding of metronidazole both in the nasal olfactory mucosa and the liver.”
“In the elongation zone, MTZ induced an increase of TBARS content and a significant rise in GSH levels, whereas in the meristematic zone, lipid peroxidation was not observed and all antioxidant defense parameters analyzed were significantly increased.”
Oxidative damage and antioxidant response of Allium cepa meristematic and elongation cells exposed to metronidazole.“A knockout of gshA , involved in glutathione biosynthesis, enhanced the susceptibility to metronidazole , while a knockout of recD, involved in recombination and repair, made the bacteria hypersusceptible to ciprofloxacin.”
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