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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Methylphenidate
Research Papers that Mention the Interaction
“Additionally, methylphenidate dose-dependently resulted in a depletion of glutathione , which was further depleted following MPTP treatment.”
Chronic methylphenidate induces increased quinone production and subsequent depletion of the antioxidant glutathione in the striatum.“In addition, lipid peroxidation increased with MPH treatment and levels of the oxidized forms of glutathione (GSSG), interleukin 1 beta (IL‑1β), tumor necrosis factor alpha (TNF‑α), and Bax increased.”
“ MPH treatment decreased levels of the reduced form of glutathione (GSH), P‑CREB, Bcl‑2, and BDNF in the hippocampus.”
“ MPH significantly increased lipid peroxidation, GSSG content, IL‐1β and TNF‐α levels in isolated tissues, and also significantly reduced GSH content, superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR) activities in hippocampus and cerebral cortex.”
“In addition, MPH at the same doses (10 and 20 mg/kg) reduced GSH , superoxide dismutase, glutathione peroxidase and glutathione reductase activity significantly in hippocampus and cerebral cortex.”
“Treatment with MPH significantly increased lipid peroxidation, mitochondrial GSH content and IL-1β and TNF-α levels in isolated hippocampal cells.”
“Additionally, MPH significantly increased Bax protein level, CaMK4 gene expression, lipid peroxidation, catalase activity, mitochondrial GSH , IL-1β, and TNF-α levels in isolated hippocampal cells.”
“Additionally, methylphenidate dose-dependently resulted in a depletion of glutathione , which was further depleted following MPTP treatment.”
Chronic methylphenidate induces increased quinone production and subsequent depletion of the antioxidant glutathione in the striatum.
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