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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Glutathione and Methyl Isocyanate

Research Papers that Mention the Interaction

Despite high reactivity, MIC can traverse cell membranes and reach distant organs, perhaps as a reversible conjugate with glutathione , which may explain some of the systemic effects of MIC.
Journal of toxicology and environmental health  •  1993  |  View Paper
Thus, conjugation of MIC with glutathione (GSH), followed by metabolism of the resulting adduct to AMCC, appears to represent a quantitatively important pathway of biotransformation of MIC in the rat.
Chemical research in toxicology  •  1991  |  View Paper
It is concluded that conjugation of methyl isocyanate with glutathione in vivo affords a reactive S-linked product which displays the potential to carbamoylate nucleophilic amino acids.
Biochemical and biophysical research communications  •  1990  |  View Paper