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Possible Interaction: Glutathione and Methotrexate

supplement:

Glutathione

Research Papers that Mention the Interaction

Further, MTX induces oxidative stress by altering the levels of ROS and glutathione cycle.
PloS one  •  2015  |  View Paper
Conversely, depletion of glutathione increased the apoptotic action of methotrexate , showing an involvement of cytochrome c redox state in methotrexate-induced apoptosis.
RESULTS Cell incubation with cytochrome c-reducing agents, such as tetramethylphenylenediamine, ascorbate or reduced glutathione , decreased the mortality and apoptosis triggered by methotrexate.
RESULTS Cell incubation with cytochrome c-reducing agents, such as tetramethylphenylenediamine, ascorbate or reduced glutathione , decreased the mortality and apoptosis triggered by methotrexate.
PloS one  •  2013  |  View Paper
At 1 microM, MTX induced differentiation was associated with a marked reduction in the intracellular concentrations of adenosine and, consequently, S-adenosylmethionine (SAM), S-adenosylhomocysteine, polyamines and glutathione (GSH).
Journal of cellular biochemistry  •  2006  |  View Paper
3 MTX treatment of monocytes (10 nM-10 micro M) for 16 h significantly reduced total GSH levels (P<0.05) independently of dose (P>0.05).
However, in T-cells, GSH levels were significantly elevated following 30 nM MTX treatment (P<0.05) but reduced by doses exceeding 1 micro M compared to controls (P<0.05).
British journal of pharmacology  •  2003  |  View Paper
MTX decreased the cellular levels of glutathione (70 per cent), while the presence of LCV and glutamine did not interfere with the effect of MTX.
Cell biochemistry and function  •  1998  |  View Paper
Results MTX induced a distinct diminution in serum activities of oxidative stress markers (SOD, CAT, GPx and GSH ), while lipid peroxidation considerably increased demonstrated by MDA level.
Integrative medicine research  •  2018  |  View Paper
Whereas total protein, albumin, total antioxidant capacity, reduced glutathione GSH ), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT) levels were significantly decreased in MTX treated group.
Asian Pacific journal of tropical medicine  •  2017  |  View Paper
Furthermore, MTX caused a significant decrease in the activities of hepatic enzymic antioxidants (superoxide dismutase, catalase, glutathione S-transferase) and nonenzymic antioxidants (Vitamin C and glutathione ), followed by a significant increase in hepatic malondialdehyde content.
Journal of xenobiotics  •  2016  |  View Paper
Several reports indicate that the effects of MTX are influenced by genetic variants, specific dynamic processes and micro-environmental elements such as nucleotide deprivation or glutathione levels.
Rheumatology  •  2007  |  View Paper
Moreover, MTX decreases hepatic GSH level, SOD, GPx and CAT activities (all p<0.001).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2017  |  View Paper
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