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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Glutathione
drug:
Methotrexate
Research Papers that Mention the Interaction
“The cumulative release of MTX in pH 5.0 medium with 10 mM GSH was 5‐fold higher than that recorded at pH 7.4 without GSH.”
pH/redox dual‐sensitive dextran nanogels for enhanced intracellular drug delivery“Several reports indicate that the effects of MTX are influenced by genetic variants, specific dynamic processes and micro-environmental elements such as nucleotide deprivation or glutathione levels.”
“Further, glutathione participates in the formation of toxic metabolites of such chemotherapeutics as azathioprine and bleomycin and may affect the cellular uptake of other agents, such as methotrexate.”
“In addition, CYP and MTX were significantly induced ROS formation, MMP collapse, lysosomal membrane damage, lipid peroxidation, and GSH depletion compared with the controls.”
“Further, MTX induces oxidative stress by altering the levels of ROS and glutathione cycle.”
“Conversely, depletion of glutathione increased the apoptotic action of methotrexate , showing an involvement of cytochrome c redox state in methotrexate-induced apoptosis.”
“Results Cell incubation with cytochrome c-reducing agents, such as tetramethylphenylenediamine, ascorbate or reduced glutathione , decreased the mortality and apoptosis triggered by methotrexate.”
“At 1 µM, MTX induced differentiation was associated with a marked reduction in the intracellular concentrations of adenosine and, consequently, S‐adenosylmethionine (SAM), S‐adenosylhomocysteine, polyamines and glutathione (GSH).”
“However, in T‐cells, GSH levels were significantly elevated following 30 nM MTX treatment (P<0.05) but reduced by doses exceeding 1 μM compared to controls (P<0.05).”
“ MTX treatment of monocytes (10 nM–10 μM) for 16 h significantly reduced total GSH levels (P<0.05) independently of dose (P>0.05).”
“ MTX decreased the cellular levels of glutathione (70 per cent), while the presence of LCV and glutamine did not interfere with the effect of MTX.”
“Moreover, MTX decreases hepatic GSH level, SOD, GPx and CAT activities (all p<0.001).”
Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats.
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