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Last Updated: 21 days ago

Possible Interaction: Glutathione and Methotrexate

supplement:

Glutathione

Research Papers that Mention the Interaction

The cumulative release of MTX in pH 5.0 medium with 10 mM GSH was 5‐fold higher than that recorded at pH 7.4 without GSH.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V  •  2017  |  View Paper
Several reports indicate that the effects of MTX are influenced by genetic variants, specific dynamic processes and micro-environmental elements such as nucleotide deprivation or glutathione levels.
Rheumatology  •  2008  |  View Paper
Further, glutathione participates in the formation of toxic metabolites of such chemotherapeutics as azathioprine and bleomycin and may affect the cellular uptake of other agents, such as methotrexate.
Cancer research  •  1984  |  View Paper
Further, MTX induces oxidative stress by altering the levels of ROS and glutathione cycle.
PloS one  •  2015  |  View Paper
Conversely, depletion of glutathione increased the apoptotic action of methotrexate , showing an involvement of cytochrome c redox state in methotrexate-induced apoptosis.
Results Cell incubation with cytochrome c-reducing agents, such as tetramethylphenylenediamine, ascorbate or reduced glutathione , decreased the mortality and apoptosis triggered by methotrexate.
PloS one  •  2013  |  View Paper
At 1 µM, MTX induced differentiation was associated with a marked reduction in the intracellular concentrations of adenosine and, consequently, S‐adenosylmethionine (SAM), S‐adenosylhomocysteine, polyamines and glutathione (GSH).
Journal of cellular biochemistry  •  2006  |  View Paper
However, in T‐cells, GSH levels were significantly elevated following 30 nM MTX treatment (P<0.05) but reduced by doses exceeding 1 μM compared to controls (P<0.05).
MTX treatment of monocytes (10 nM–10 μM) for 16 h significantly reduced total GSH levels (P<0.05) independently of dose (P>0.05).
British journal of pharmacology  •  2003  |  View Paper
MTX decreased the cellular levels of glutathione (70 per cent), while the presence of LCV and glutamine did not interfere with the effect of MTX.
Cell biochemistry and function  •  1998  |  View Paper
Moreover, MTX decreases hepatic GSH level, SOD, GPx and CAT activities (all p<0.001).
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2018  |  View Paper
However, MTX administration decreased reduced glutathione content plus catalase activity.
Journal of biochemical and molecular toxicology  •  2017  |  View Paper
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