Possible Interaction: Glutathione and Methionine

“ Methionine supplemented at 3.2 and 4.0 g/kg significantly increased glutathione concentration in the egg yolk compared with 5.4 g of Met/kg (P < 0.01) and increasing Met supplementation increased the glutathione concentration in the egg albumen.”

“ Methionine intakes above approximately 1 g/d transiently raise plasma Tau, Hcy, and GSH.”

“ Methionine starvation leads to depleted methionine levels in cells, modifies methylation reactions, lowers glutathione levels and alters folate distribution and leads to a tumor-selective cell cycle arrest in late-S/G2.”

“Use of the adaptive model to analyze the functioning of the glutathione network revealed that a threshold input concentration of methionine may be required for effective detoxification of reactive metabolites by glutathione conjugation.”

“B[a]P significantly lowered total cellular glutathione (GSH) level, but co-cultured with B[a]P and methionine , gradually attenuated intracellular GSH levels in a concentration-dependent manner, which was markedly higher at 20-500μM methionine.”

“Our data suggests that methionine might exert a chemoprotective effect on B[a]P-DNA adduct formation by attenuating intracellular GSH levels, blocking the uptake of B[a]P into cells, or by altering expression of proteins involved in DNA adduct formation.”

“Inhibition of active GSH extrusion from the cell by cystathionine or methionine completely reversed lipid peroxidation and apoptosis.”

“The reduced flux of methionine along the transmethylation/transsulfuration pathway reduces GSH synthesis in cirrhosis.”

“Leucine, alpha-ketoisocaproate, and methionine (carboxyl carbon, methyl moiety, remethylation, and transsulfuration) turnover were reduced during GSH administration (P < 0.01).”

“ Methionine (1mM) decreased GSH efflux from the cells, although total GSH content in the cells was not affected during the incubation time of 60 min.”

“2) Cysteine and methionine increase the amount of glutathione in the liver.”