Possible Interaction: Glutathione and Manganese

“ Mn exposure (5-15mM, 5d) among male flies, besides induction of oxidative stress (elevated levels of MDA and protein carbonyls with a concomitant decrease in glutathione levels ), caused significant perturbations in the activities of antioxidant enzymes and mitochondrial complexes.”

“Because BSO treatment accentuated Mn toxicity in both cell lines, GSH may act to combat Mn toxicity.”

“Thus, these results indicate that Mn supplementation can improve the developmental competence of porcine PA and SCNT embryos by increasing GSH and decreasing ROS levels.”

“The group exposed to Al + Mn exhibited several alterations, including increased concentration of GSH , as well as higher GPx and GR activity in the gills.”

“In conclusion, excessive exposure to Mn disrupts GSH synthesis through inhibition of EAAC1 and xCT to trigger oxidative damage in the striatum.”

“ Mn also decreased the level of GSH , sulfhydryl, and increased ROS, MDA, 8-OHdG, and carbonyl in a dose-dependent manner.”

“Furthermore, Mn administration increased brain Mn concentrations and induced superoxide dismutase, catalase, and glutathione depletion.”

“Ascorbate, glutathione and glutathione ethyl ester weakly protected against motor deficits and reduced MN death by only 30–40%.”

“ Mn exposure caused a marked oxidative stress in cerebellum as indicated by a significant decrease … and glutathione peroxidase and in the levels of non-enzymatic antioxidants like reduced glutathione ( GSH ), total thiols and vitamin C. Conversely an increase was obtained … acid substances, lipid hydroperoxide and protein carbonyl products contents.”

“ Mn significantly decreased levels of DA and GSH and increased levels of DHAA and uric acid both in the striatum and synaptosomes.”

“The content of GSH in myocytes also decreased after manganese exposure.”