Possible Interaction: Glutathione and Malathion

“ Malathion significantly reduced GSH content, but pre-treatment with EGCG significantly recovered GSH content.”

“In low doses, malathion caused mild depletion of GSH , threefold increase in HSP27 level and a range bound cytotoxicity and apoptosis of PBMC.”

“ Malathion under in vitro condition even at lower concentration (250 ppm) altered the level of enzymes associated with glutathione cycle and antioxidant defence system in human fetal brain and liver.”

“Rats treated with Ctp, Mtn and Ctp + Mtn displayed significant alterations in the levels of antioxidative indices (MDA, GSH , GST, GPx, SOD and CAT).”

“ Malathion resulted in an increase in MDA, nitric oxide; a decrease in GSH and PON1 activity in different brain regions.”

“Crocin (10, 20, and 40 mg/kg) or levodopa plus malathion decreased MDA and increased GSH.”

“Results showed that malathion induced neurobehavioral impairments together with elevation of MDA, TNF-α and IL-6 levels, reduction of GSH , and AChE activity.”

“ MAL did significantly reduce the GSH levels, but SFN and CUR increased these levels by blocking the MAL effect in the liver tissues.”

“ Malathion and chlorpyrifos decreased GSH contents and the ratio of GSH/GSSG.”

“… malathion as individual pesticides … to react with glutathione (GSH) during their metabolism and alterations in rat blood and liver GSH content after subacute exposure to this combination were noted … work from this laboratory, it is important to examine the glutathione related parameters in the rat liver and kidneyin vitro.”

“Daily exposure to concentrations of 50 mg/kg carbaryl and/or malathion for 21 days produced a 20% decrease in hepatic GSH content.”