Possible Interaction: Glutathione and Lysine

“ L-Lysine significantly reduced the magnitude of lipid peroxidation; total protein content; wet/dry ratio of lung tissue; tumor necrosis factor-…, and macrophage inhibitory factor levels; MPO activity; and total cell, neutrophil, and lymphocyte counts, and it increased the reduced glutathione levels and the glutathione … dismutase, and catalase activities.”

“Moreover, Lys induced lipid peroxidation and diminished the concentrations of glutathione 2 h after injection.”

“Furthermore, the inhibitory effect of Lys on tCK activity was totally prevented by reduced glutathione , suggesting a possible role of reactive species oxidizing critical thiol groups of the enzyme.”

“Finally, lysine markedly oxidized a glutathione commercial solution in a medium devoid of brain supernatants, indicating that it behaved as a direct acting oxidant.”

“ Lysine also significantly diminished glutathione levels in cortical supernatants, decreasing, therefore, the major brain antioxidant defense.”

“By normalizing the transport activity for compounds by … indicated that the site-directed mutagenesis from Lys to Met at 325 (K325M) and … reduction in the transport for glutathione conjugates [2,4-dinitrophenyl-S-glutathione (DNP-SG) and leukotriene (LT) …-2-methylamino-4-(3-pyridymethyl) benzothiazole glucuronide and taurolithocholate sulfate.”

“The stimulatory effect of GSH on incorporation of both lysine and arginine was most marked in the nuclei of preleptotene primary spermatocytes.”