supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
Glutathione
supplement:
Lycopene
Research Papers that Mention the Interaction
“We also found that lycopene increased the intracellular glutathione ( GSH ) level and glutamate-cysteine ligase expression.”
Lycopene inhibits NF-κB activation and adhesion molecule expression through Nrf2-mediated heme oxygenase-1 in endothelial cells.“We found that lycopene increases intracellular GSH levels and GCL expression.”
“Similarly, the levels of GSH were significantly increased (P < 0.05, P < 0.01) after the Ly treatment.”
Hepatoprotective and antioxidant effects of lycopene on non-alcoholic fatty liver disease in rat“ Lycopene prevented ZEA-induced changes in GSH levels and inhibited the processes of inflammation, reducing the damage induced by ZEA.”
“Moreover, lycopene inhibited the formation of reactive oxygen species and malondialdehyde, prevented the loss of glutathione , and affected the activities of a battery of oxidant enzymes in the skin of mice.”
“Pretreatment with lycopene restored significantly malondialdehyde and reduced glutathione concentrations.”
“Apparently lycopene participated as an antioxidant agent and also protecting the cellular level of GSH.”
“Furthermore, the inhibitory role of lycopene in GSH depletion was found to be associated with the prevention of OGD‑induced depletion of intracellular cysteine and downregulation of xCT.”
Lycopene prevents oxygen-glucose deprivation-induced autophagic death in SH-SY5Y cells via inhibition of the oxidative stress-activated AMPK/mTOR pathway.“ Lycopene increased the hepatic levels of total protein and albumin and reduced glutathione.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback