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Last Updated: 2 years ago

Possible Interaction: Glutathione and Lidocaine

supplement:

Glutathione

Research Papers that Mention the Interaction

These data suggest lidocaine induces perpetual mitochondrial depolarization, ROS/RNS generation along with increased glutathione to combat the oxidative cellular environment, glycolytic to PPP cycling of carbon generating NADPH, obstruction of carbon flow through the TCA cycle, decreased ATP generation, and metacaspase dependent apoptotic cell death.
Redox biology  •  2017  |  View Paper
Lidocaine causes an increased concentration of GSH and GSSG in the hippocampus from the first day.
Life sciences  •  2008  |  View Paper
Furthermore, lidocaine also regulated the levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), IL-6, IL-10, iNOS, and IL-4.Notably, lidocaine markedly inhibited the expression of p65 and p38.
Annals of translational medicine  •  2020  |  View Paper