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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Levodopa
Research Papers that Mention the Interaction
“Interestingly, patients treated with PM + l-DOPA showed a significantly increased level of glutathione compared with those treated with l-DOPA alone.”
Pergolide Mesylate, a Dopaminergic Receptor Agonist, Applied With l-DOPA Enhances Serum Antioxidant Enzyme Activity in Parkinson Disease“Our results show that l-dopa , but not carbidopa, decreases the markers of lipid and protein oxidation and increases the total content of glutathione.”
“ Glutathione , had neurotrophic effects on untreated midbrain dopamine neurons and prevented the effect of L-DOPA.”
Glia protect fetal midbrain dopamine neurons in culture from L-DOPA toxicity through multiple mechanisms“ Levodopa toxicity to cultured dopaminergic neurons was enhanced by glutathione depletion and diminished by antioxidants.”
“However, L-DOPA increased the level of glutathione.”
“These data suggest that the neurotrophic effect of L-DOPA may be mediated, at least in part, by elevation of glutathione content.”
“Reduced glutathione , ascorbate, superoxide dismutase, and catalase prevented the effect of levodopa and dopamine on complex I. Various inhibitors of monoamine oxidase also prevented the effect of dopamine.”
“Our findings indicate that the GSH-LD codrug offers advantages deriving from the additive effect of LD and GSH and it could represent a promising candidate for PD treatment.”
Modulation of Apoptotic Cell Death and Neuroprotective Effects of Glutathione—L-Dopa Codrug Against H2O2-Induced Cellular Toxicity“Additionally, coadministration of GSH + Tet appeared to offset the possible oxidative neurotoxicity induced by L-dopa.”
“ Glutathione dose dependently inhibited melanin synthesis in the reaction of tyrosinase and L-DOPA.”
“ Glutathione inhibited the binding between tyrosinase and L-DOPA.”
“These results indicate that glutathione inhibits the synthesis and agglutination of melanin by interrupting the function of L-DOPA.”
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