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Last Updated: 2 years ago

Possible Interaction: Glutathione and Ketoconazole

supplement:

Glutathione

Research Papers that Mention the Interaction

The coincubation of ketoconazole suppressed the generation of the GSH conjugate.
Chemical research in toxicology  •  2011  |  View Paper
In addition, the level of these GSH conjugates in human microsomes was reduced upon the addition of a CYP3A4 inhibitor ketoconazole.
Chemical research in toxicology  •  2009  |  View Paper
Ketoconazole significantly inhibited the formation of the glutathione conjugates (M1 and M2) in microsomal incubation and similar finding was obtained in vivo.
Chemical research in toxicology  •  2020  |  View Paper
Pretreatment with ketoconazole prevented the animals from developing EEA-induced liver injury, caused 7- and 13-fold increases in the plasma Cmax and AUC of EEA, and decreased urinary excretion of glutathione conjugates derived from EEA.
Chemical research in toxicology  •  2016  |  View Paper
We further hypothesized that glutathione and heme catabolism may be interfered by KTZ and FCZ, resulting in an increased efficacy of ART in PvAR parasite.
Parasitology Research  •  2015  |  View Paper
Furthermore, Keto inhibited the LUT‐induced GSH exhaustion.
Journal of applied toxicology : JAT  •  2015  |  View Paper