Possible Interaction: Glutathione and Ketamine

“In addition, ketamine treatment caused significant glutathione depletion, lipid peroxidation and reduction in catalase activity.”

“… ketamine administration increased MDA ( p < 0.001), TNF-α ( p < 0.01), IL-6 ( p < 0.01), COX-2 ( … TnI ( p < 0.001), CK-MB ( p < 0.001) and CK ( p < 0.01) levels whereas decreased GSH ( p < 0.05) and Nrf-2 ( … CAT ( p < 0.05) enzyme activities.”

“The study demonstrated that, in the uterine and … tissues of rats that have been administered ketamine , there was a decrease in the levels of total glutathione and superoxide dismutase, while malondialdehyde and myeloperoxidase was increased: however it was observed that these ratios were reversed in the ketamine+nimesulide group.”

“In addition, the administration of KET decreased GSH and increased nitrite, lipid peroxidation and myeloperoxidase activity.”

“Morin alone or in combination with ketamine significantly increased glutathione concentration, superoxide dismutase and catalase activities compared with saline- or ketamine-treated mice.”

“ Ketamine inhibited chemical- or ischemia-induced lipid peroxidation as well as ischemic glutathione depletion.”

“Furthermore, ketamine treatment increased the urination rate (P<0.05), pathological score (P<0.05), levels of the oxidative stress product malondialdehyde (P<0.05) in addition to reducing the expression of the anti-oxidative stress enzyme superoxide dismutase (P<0.05) and glutathione-SH (P<0.05).”