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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Kava
Research Papers that Mention the Interaction
“Addition of GSH to kava extracts has been shown to reduce cytotoxicity in vitro, which suggests the presence of inherently reactive constituents.”
Constituents in kava extracts potentially involved in hepatotoxicity: a review.“APAP-induced glutathione GSH ) depletion was also potentiated by kava.”
“These observations indicate that kava potentiates APAP-induced cytotoxicity by increasing the magnitude of GSH depletion, resulting in oxidative stress and mitochondrial dysfunction, ultimately leading to cell death.”
“The Michael reaction between glutathione and kava lactones , resulting in opening of the lactone ring, reduces the side effects of the kava kava extracts.”
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