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Last Updated: a year ago

Possible Interaction: Glutathione and Kaempferol





Research Papers that Mention the Interaction

Kaempferol pretreatment blocked AA+Fe-induced ROS production and reversed glutathione depletion, which in turn led to decreased cell death.
Journal of medicinal food  •  2019  |  View Paper
We found that short term exposure of human bronchial epithelial cells (BEAS-2B) to Cr(VI) (5μM) showed a drastic increase in ROS generation, NADPH oxidase (NOX) activation, lipid peroxidation, and glutathione depletion, which were significantly inhibited by the treatment with luteolin in a dose dependent manner.
Toxicology and applied pharmacology  •  2014  |  View Paper
Luteolin also inhibited Nrf2 target gene [NQO1, heme oxygenase-1 (HO-1) and GSTα1/2] expression and decreased reduced glutathione in wild type mouse small intestinal cells.
Asian Pacific journal of cancer prevention : APJCP  •  2014  |  View Paper
Kaempferol significantly reduced the depletion of hepatic glutathione and prevented the increase in MDA formation in mice.
The AAPS Journal  •  2013  |  View Paper
Luteolin increased the level of reduced glutathione ( GSH ) and the expression of GSH synthetase, which catalyzes the second step of GSH biosynthesis.
International journal of oncology  •  2017  |  View Paper
With respect to CDNB, the luteolin-SG conjugate inhibited GST activity via competitive … irreversible mixed inhibition of GST activity with Ki of 0.039 μM. Luteolin (100 … to GSH and non-competitively with respect to CDNB with Ki of …-99% GST inhibition in human SK-MEL-28 cell homogenate.
Chemico-biological interactions  •  2015  |  View Paper
In both the controls and APAP-treated rats, kaempferol significantly increased the hepatic levels of glutathione (GSH) and superoxide dismutase, suppressed MDA and reactive oxygen species (ROS) levels, increased protein levels of Bcl-2 and downregulated protein levels of Bax and cleaved Bax.
Pharmaceutical biology  •  2021  |  View Paper
In addition, KMP increased the levels of SOD and glutathione in the hippocampus of rats.
Neurochemical research  •  2021  |  View Paper
KA pretreatment significantly reduced the levels of aspartate aminotransferase (AST) … hepatocellular damage and apoptosis, attenuated the exhaustion of glutathione (GSH) and accumulation of malondialdehyde (MDA), increased the expression of antioxidative enzymes (e.g., heme … NADPH quinone oxidoreductase 1 (NQO1)), and thus restrained APAP-induced oxidative damage in the liver.
Food & function  •  2020  |  View Paper
In both control and CdCl 2 -treated rats, Kaempferol significantly increased hippocampal levels of GSH levels and protein levels of Nfr2, Bcl2 and synaptic proteins (SNAP-25, PSD-25, and synapsin).
Neurochemical Research  •  2019  |  View Paper
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