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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Glutathione
drug:
Iproplatin
Research Papers that Mention the Interaction
“Our results, from the analyses of both GSH concentration as well as GSH per cell number, suggest a significantly higher interaction between GSH and iproplatin compared with the other platinum agents.”
Intracellular glutathione and cytotoxicity of platinum complexes“Abstract Previous studies from our laboratory have indicated that glutathione (GSH) may affect the cytotoxicity of iproplatin to a greater extent than four other platinum agents tested including cisplatin.”
“At 85% depletion of GSH , cytotoxicity of iproplatin was increased by a factor of >7 and that of cisplatin by <2.”
“These results confirm the previous finding that GSH interferes with the cytotoxicity of iproplatin to a significantly greater extent than that of cisplatin.”
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