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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Insulin
Research Papers that Mention the Interaction
“Reduced glutathione had no effect on IDE, but reacted with partially degraded insulin to disrupt its disulfide bonds and accelerate its breakdown to trichloroacetic acid soluble fragments.”
Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme“The three disulphide bonds of insulin were reduced by glutathione.”
“Moreover, cells treated with insulin increased the H2O2-induced suppression of glutathione levels and exerted an apparent suppressive effect on oxidative products.”
“Moreover, cells treated with insulin increased H2O2-induced suppression of glutathione levels and exerted an apparent suppressive effect on oxidative products.”
“The insulin release from Eul-cys/GSH and Eul-cys NPs in PBS (pH 7.4) shows that GSH can slightly decrease the release rate of insulin.”
“Among the excipients studied, 1mM of TETA, EDTA, or GSH prevented insulin aggregation upon metal catalyzed oxidation (MCO) for 3h at room temperature, based on size exclusion chromatography (SEC).”
“The decrement of red cell GSH may be due to the higher rate of consumption of GSH , increasing GPx activity or a reduction of pentose phosphate pathway, stimulated by insulin , resulting in lowered GSH recycle.”
“In vitro insulin treatment (10(-9) M) resulted in increase in the GSH content in both normal and type 2 diabetic erythrocytes.”
“Both epidermal growth factor (0.1-10 ng/ml) and insulin (1 microgram/ml) significantly increased GSH efflux from Hep G2 cells.”
“It was found that in the series of rats receiving 5 units of insulin the content of glutathione of the liver was decreased in a straight line relationship with time for periods of about 90 minutes.”
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