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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
supplement:
Inosine
Research Papers that Mention the Interaction
“As was the case for cytotoxicity, the magnitude of GSH depletion by any given INO dose was highly dependent on cell concentration, being greatest at low cell densities.”
Cytotoxicity and glutathione depletion by 1-methyl-2-nitrosoimidazole in human colon cancer cells.“Further, inosine significantly reduced lipid peroxidation and nitrite, and increased the levels of reduced glutathione and superoxide dismutase.”
Inosine improves cognitive function and decreases aging-induced oxidative stress and neuroinflammation in aged female rats“In addition, inhibition of GSH synthesis greatly potentiated the manganese-induced increase in inosine, …, xanthine and uric acid levels in both regions of aged rats; moreover, inhibition of GSH synthesis … increased inosine , hypoxanthine, xanthine and uric acid levels in both regions … young rats, compared with the manganese-treated group.”
“At 10(6) cells/ml, INO depleted GSH , in the range of concentrations where toxicity was observed, down to a plateau of 15% of the control level at a concentration of 100 microM INO.”
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