Possible Interaction: Glutathione and Indomethacin

“ Indomethacin is known to decrease cellular GSH levels [4].”

“ Indomethacin treatment decreased glutathione content and glutathione-conjugates in K562/ADR cells.”

“… indomethacin (20 μM) … decreased glutathione levels by 31.5% in GLC4-Adr, complete depletion of cellular glutathione by L-buthionine (S,R)-sulphoximine only resulted in a … indomethacin-induced apoptosis in GLC4-Adr, demonstrating that a reduced cellular glutathione level is not the primary cause of indomethacin-induced apoptosis.”

“In addition, indomethacin exposure increased intracellular glutathione content as well as inhibited glutathione depletion and cytotoxicity caused by diethyl maleate.”

“The oxidation of erythrocyte glutathione was inhibited by the presence of the cyclooxygenase inhibitor indomethacin , suggesting that this may be of value in the treatment of oxidative pathologies.”

“The … indomethacin caused a decrease … the levels of glutathione , mucus, hexosamine and in the activities of glutathione-S-transferase, sodium-potassium ATPase, thromboplastic activity and an increase in the … and alanine amino transferase, alkaline phosphatase, catalase, lactate dehydrogenase, myeloperoxidase activities and sialic acid, lipid peroxidation and protein carbonyl levels.”

“Results show that INDO treatment decreased the GSH , SOD, and CAT levels/activities and increased the LPO, ALT, AST, ALP, and TBIL activities/levels.”

“On the other hand, indomethacin decreased glutathione , nitrite/nitrate contents and superoxide dismutase activity.”

“Furthermore, the administration of indometacin caused a significant decrease in the levels of superoxide, glutathione peroxidase and reduced glutathione and an increase in the lipid peroxidation level.”

“Esomeprazole (10–60 µmol/kg) dose dependently reversed, up to complete recovery, the inhibitory effect of indomethacin on GSH levels (approximately 60% inhibition) and mitochondrial enzyme activities (inhibition ranging from 60% to 75%).”