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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Glutathione
drug:
Icaritin
Research Papers that Mention the Interaction
“10 μM ICT treatment resulted in significant AKT activation, Nrf2 nuclear translocation, increased GCL transcription and GSH levels, as compared with CSE exposure alone.”
“These findings suggest that ICT attenuates CS-induced oxidative stress by quenching ROS and also by upregulating GSH via a PI3K-AKT-Nrf2-dependent mechanism.”
Icaritin attenuates cigarette smoke-mediated oxidative stress in human lung epithelial cells via activation of PI3K-AKT and Nrf2 signaling.“The results of … showed that icaritin could significantly increase the level of … lactate dehydrogenase, reduce the level of glutathione , improve the quality of reactive oxygen species and reduce mitochondrial membrane potential, indicating that it … by destroying cell membrane structure, inhibiting antioxidant enzyme activity, activating oxidative stress and inducing apoptosis.”
[Potential hepatotoxic compounds and mechanisms of Epimedii Folium based on network toxicology and cell experimental validation].
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