Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Glutathione and Hypochlorite

supplement:

Glutathione

Research Papers that Mention the Interaction

As HOCl has been shown to react with thiol-containing compounds like glutathione and N-acetylcysteine protecting LDL from HOCl modification, we have tested the ability of hydrogen sulfide (H2S)—which has recently been identified as an endogenous vasorelaxant—to counteract the action of HOCl on LDL.
Free radical research  •  2007  |  View Paper
In conclusion, exposure to HOCl causes the irreversible loss of cellular GSH with the formation of novel products that are rapidly exported from the cell, and resynthesis of GSH will be required to restore levels.
Treatment of cells with hypochlorous acid (HOCl) at sublethal doses causes a concentration-dependent loss in reduced glutathione ( GSH ) levels.
The Journal of Biological Chemistry  •  2001  |  View Paper
Antioxidant defenses such as reduced glutathione and glucose-6-phosphate dehydrogenase were depleted or inactivated at 10 microM HOCl , while other activities, such as superoxide dismutase, dropped only above 57 microM HOCl.
Archives of biochemistry and biophysics  •  1999  |  View Paper
These results indicate that HOCl can penetrate the red cell membrane, which provides little barrier protection for cytoplasmic components, and that GSH oxidation by HOCl may be a highly selective process.
This indicates that in metabolically active cells regeneration is rapid and GSH may protect cell components from damage by HOCl.
The Biochemical journal  •  1995  |  View Paper
We initially postulated that ELF total protein and glutathione would account for most of the inhibition of HOCI.
The American review of respiratory disease  •  1991  |  View Paper
Additionally, intracellular glutathione GSH ), which is the prime scavenger for HOCl in cells, decreased within the first hour of HOCl exposure.
Toxicology and applied pharmacology  •  2008  |  View Paper
The effects of HOCl on the isolated organ and the enzyme preparation could be precluded with thiol group-containing compounds such as reduced glutathione and N-acetylcysteine.
Toxicology and applied pharmacology  •  2002  |  View Paper
HOCl (100 microM) reduced viability to 25 +/- 1% of controls and taurine, beta-alanine and glutathione at 1 mM provided nearly complete protection.
Advances in experimental medicine and biology  •  2000  |  View Paper
glutathione (1,000 μM) inhibited the loss of ATP after both exposure to 250 μM H2O2 (24 ± … ATP without glutathione compared with 13 ± 2% loss with glutathione, P < 0.05), and 250 μM hypochlorous acid (12 ± 2% loss of ATP without glutathione … 1 ± 1% increase of ATP with glutathione).
The American journal of the medical sciences  •  1995  |  View Paper
Only H2O2 oxidized GSH quantitatively to its disulfide; HOCl oxidized GSH to higher oxidation states.
Circulatory shock  •  1994  |  View Paper
Show More