Possible Interaction: Glutathione and Hydroxytyrosol

“It was also found that HT concentration-dependently attenuated GSH depletion in HepG2 cells treated with 10mM AA.”

“ HT at 50 and 100 microM concentrations increased the GSH level.”

“Treatment with HT inhibited the incidence of oxidative damage in splenic tissue through decreasing lipoperoxidation and increasing antioxidant molecules, namely glutathione , superoxide dismutase and catalase.”

“(-)-Epigallocatechin-3-gallate or HTyr treatments induced higher concentrations of intracellular GSH compared to control cells, matched by an increase of γ-glutamylcysteine ligase activity mainly in cells treated with HTyr.”

“Finally, flow cytometric analysis revealed that both TPF and HT improved the redox status by increasing the levels of GSH , one of the most important antioxidant molecules, in both endothelial cells and myoblasts, while the ROS levels were not significantly affected.”

“We show that HT modulates the antioxidant network in the adipose tissue, as mediated by glutathione (GSH) and associated enzymes.”

“An increase in the GSH/GSSG ratio at the highest dose was observed indicating that the products of HT autoxidation are counteracted by glutathione , resulting in their detoxification.”

“ Hydroxytyrosol reduced oxidative stress parameters: it inhibited lipid peroxidation and increased enzymatic activities related with the glutathione system both in vitro and after oral administration to rats.”

“Moreover, HT effectively suppressed OPP-induced ROS formation, and increased the GSH level.”

“The protective effects of HT against CDDP-induced injury were partly reversed on CKLF1 overexpressed … cells, which shown by decreased cell viability and increased activation of NF-κB. HT also up-… activities of GSH and SOD decreased by CDDP, and inhibited the … of MDA and NO induced by CDDP.”