Possible Interaction: Glutathione and Hydroquinone

“… glutathione (3 mM) also prevented the … of SCEs by catechol or hydroquinone , active metabolites of benzene and potent inducers of SCEs, strongly suggesting that glutathione did not simply inhibit the activity … S-9 mix to activate benzene but actually prevented the production of DNA lesions by the active metabolites.”

“ HQ increased intracellular MDA and LPO and decreased the activities of GSH , GSH-Px, and SOD in hepatic L02 cells.”

“ Hydroquinone either alone or in the presence of copper produced a decrease of reduced glutathione level without altering methemoglobin concentration and erythrocyte lipid peroxidation.”

“The present study showed that HQ induced the increased levels of ROS and depletion of GSH in HepG2 cells, the doses being 25-50 and 6.25-50 microM, respectively.”

“Intracellular thiol, including glutathione and protein thiol, was decreased following treatment with HQ.”

“ HQ treatment also resulted in a significant depletion of cellular GSH , which preceded the loss of cell viability.”

“Therefore, the above results suggest that GSH but not QR is an important factor involved in the toxicodynamics of HQ in these myeloid cells.”

“With hydroquinone, GSH was virtually depleted before small amounts of methaemoglobin were produced.”

“ Glutathione conjugation of HQ enhances its biological reactivity, and 2,3,5‐tris‐(glutathion‐S‐yl)hydroquinone (TGHQ) is a potent nephrotoxicant and nephrocarcinogen in the Eker rat.”

“The inhibition of exogenous NO by hydroquinone was completely prevented by urate and GSH.”

“Although the mechanism of HQ-mediated nephrocarcinogencity in male F344 rats is not known, GSH conjugates of HQ may play an important role.”