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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Glutathione
drug:
Hydralazine
Research Papers that Mention the Interaction
“Consideration of the time-dependent nature of hydralazine inhibitory activity toward AO when designing this experiment could have predicted the potential for GSH to interfere with hydralazine.”
“The presence of GSH was found to interfere with the inhibitory activity of hydralazine.”
Case Study 11: Considerations for Enzyme Mapping Experiments-Interaction Between the Aldehyde Oxidase Inhibitor Hydralazine and Glutathione.“ Hydralazine also prevented DAS induced GSH depletion, decreased mitochondrial membrane potential and increased ROS and TBARS formation.”
The molecular mechanisms of diallyl disulfide and diallyl sulfide induced hepatocyte cytotoxicity.“Specifically, hydralazine (500 μmol/L to 1 mmol/L) can significantly alleviate acrolein (100–500 μmol/L)‐induced superoxide production, glutathione depletion , mitochondrial dysfunction, loss of membrane integrity, and reduced compound action potential conduction.”
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