Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Glutathione and Homocysteine

supplement:

Glutathione

supplement:

Homocysteine

Research Papers that Mention the Interaction

It was hypothesised that sufficient Se reduces the flux of HCys through the transsulphuration pathway by decreasing the expression of glutathione (GSH) synthesising enzymes.
Food & function  •  2011  |  View Paper
In the presence of adequate estradiol levels, inverse association was observed between glutathione and homocysteine.
Clinical nutrition ESPEN  •  2017  |  View Paper
A five-day incubation with Hcy (∼25 μM) increased reactive oxygen species, peroxide lipids, as well as 8-hydroxyguanosine levels by twofold, and decreased the endogenous cell antioxidant defenses, that is reduced glutathione , by 50% in Hcy-exposed cultures compared with controls (p < 0.01).
Free radical research  •  2015  |  View Paper
Homocysteine stimulated MCP-1 mRNA expression and protein production in a time-dependent and dose-dependent manner in endothelial cells, decreased intracellular glutathione ( GSH ) and protein thiol levels, as well as G6PDH activity and NADPH levels.
Journal of cardiovascular pharmacology  •  2003  |  View Paper
Intracellular concentrations of glutathione in HeLa cell cultures were lowered after addition of agents mainly exerting oxidative stress ( homocysteine and hydrogen peroxide), whereas thiol reactive oxidative agents (mercury ions, copper ions and hydroquinone) in concentrations not affecting cell growth seemed to stimulate the production of glutathione.
Clinica chimica acta; international journal of clinical chemistry  •  1999  |  View Paper
The redox state of homocysteine in plasma may be influenced by other thiols (9), such as glutathione , which is involved in maintaining the intracellular thiols in reduced form.
Clinical chemistry  •  1999  |  View Paper
In HeLa cell lines with initial low cell density and in an endothelial cell line (ECV 304), even the presence of 100 micromol/l of homocysteine and 10 micromol/l of copper ions inhibited cell growth and decreased the cellular level of glutathione.
Toxicology  •  1997  |  View Paper
In an endothelial cell line even the presence of 500 mumol/l of homocysteine and 50 mumol/l of copper ions inhibited the cell growth and decreased the cellular level of glutathione.
Clinica chimica acta; international journal of clinical chemistry  •  1997  |  View Paper
GSH levels increased by ˜20% within 24 h exposure to Hcy.
Experimental eye research  •  2019  |  View Paper
Hcy treatment significantly increased malondialdehyde, nitrite level, acetylcholinestrase activity, tumor necrosis factor-alpha, interleukin-1 beta, glial fibrillary acidic protein, inducible nitric oxide synthase, endothelial nitric oxide synthase and decreased glutathione level indicating oxidative-nitrosative stress and neuroinflammation as compared to control and aCSF-treated groups.
Neuroscience  •  2013  |  View Paper
Show More